The paper focuses on the assessment of the Macedonian business environment based on analysis and comparison of selected global indices and ranks of competitiveness and quality of the business regulation and on the evaluation of the foreign trade relations with the Slovak Republic based on the calculation of the Revealed Comparative Advantage (RCA) Index. The Macedonian market has the potential to develop foreign trade activities with Slovak business entities, on the other hand, it is also a problematic territory to a certaint extent, as the current development of Macedonia is marked by the tense internal political situation that has persisted since the elections in April 2014.